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(DOWNLOAD) "Since the Publication of the South African Hypertension Guidelines in 2006 Several Landmark Clinical Trials have been Published Or Presented That have Far-Reaching Implications for the Way We Treat Patients with Hypertension. In Addition, The Review of a Recent Study That had Major Impact on Nephrological Practice has been Seriously Questioned (What's New in Hypertension?)" by CME: Your SA Journal of CPD # eBook PDF Kindle ePub Free

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Since the Publication of the South African Hypertension Guidelines in 2006 Several Landmark Clinical Trials have been Published Or Presented That have Far-Reaching Implications for the Way We Treat Patients with Hypertension. In Addition, The Review of a Recent Study That had Major Impact on Nephrological Practice has been Seriously Questioned (What's New in Hypertension?)

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eBook details

  • Title: Since the Publication of the South African Hypertension Guidelines in 2006 Several Landmark Clinical Trials have been Published Or Presented That have Far-Reaching Implications for the Way We Treat Patients with Hypertension. In Addition, The Review of a Recent Study That had Major Impact on Nephrological Practice has been Seriously Questioned (What's New in Hypertension?)
  • Author : CME: Your SA Journal of CPD
  • Release Date : January 01, 2009
  • Genre: Health & Fitness,Books,Health, Mind & Body,
  • Pages : * pages
  • Size : 132 KB

Description

COOPERATE study The COOPERATE study reported that progression of chronic kidney disease was retarded to a greater extent with dual blockade of the renin-angiotensin system (RAS) compared with either an ACE inhibitor or angiotensin receptor blocker (ARB) alone. (1) However, in a review of the literature to prepare a meta-analysis of the effect of monotherapy or combination therapy of RAS inhibitors on proteinuria, Kunz et al. stated that they 'excluded 1 eligible study' because of serious implausibilities in the study that could not be resolved by the publishing journal. (2,3) This included a highly unusual distribution of baseline variables, discrepancy in the statistical method and problems with patient satisfaction. They went on further to state: 'The number and seriousness of the inconsistencies found in the Nakoa article led us to wonder whether it is possible that this is only a case of extremely sloppy reporting or a hint to more severe problems with the data.' This trial has had a major influence on nephrological practice as many nephrologists were using combination therapy for protecting the kidney against progressive chronic kidney disease. This practice has to be reconsidered, especially in the light of the combination arm in the ONTARGET study (see below).


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